Answer
Combining disopyramide phosphate with clarithromycin is not recommended because it increases cardiac arrhythmia risk, including Torsades de pointes, and CYP3A inhibition may raise disopyramide levels unpredictably.
Sources for this answer
- Disopyramide Neon 250 mg Prolonged-Release TabletsNeon Healthcare Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated
Sources checked