dexrazoxane · Medicine question

Why is combining dexrazoxane with phenytoin not recommended?

iatroX medicinesPublished 8 November 2026

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Combining Savene (dexrazoxane) with phenytoin is not recommended because cytotoxic agents may reduce phenytoin absorption, potentially worsening convulsions.

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Savene 20 mg/ml powder and solvent for concentrate for solution for infusionCNX Therapeutics Ltd (formerly Sunovion Pharmaceuticals Europe) · emc · SmPC §4.5 Interaction with other medicinal products · Version 1Document updated 15 October 2024

Sources checked 8 November 2026

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