Answer
The bumetanide component of amiloride hydrochloride + bumetanide may increase aminoglycoside ototoxicity, potentially causing irreversible damage, so concurrent use is prohibited unless there are compelling medical reasons and careful medical supervision.
Sources for this answer
- Bumetanide/Amiloride 1mg/5mg TabletsChemidex Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated
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