sofosbuvir · Medicine question

Why is close INR monitoring recommended when Sovaldi (sofosbuvir) is taken with vitamin K antagonists?

Name: Why is close INR monitoring recommended when Sovaldi (sofosbuvir) is taken with vitamin K antagonists?
Published: 2026-11-08T02:03:07.427Z

iatroX medicinesPublished 8 November 2026

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Close INR monitoring is recommended with all vitamin K antagonists because liver function may change during treatment with Sovaldi (sofosbuvir).

Sources for this answer

Sovaldi 400 mg film-coated tabletsGilead Sciences Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 4Document updated 13 February 2024

Sources checked 8 November 2026

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