Answer
Clarithromycin is contraindicated with simvastatin or lovastatin because these statins are extensively metabolised by CYP3A4, and clarithromycin increases their plasma concentrations, increasing the risk of myopathy, including rhabdomyolysis.
Sources for this answer
- Clarithromycin 500 mg powder for concentrate for solution for infusionhameln pharma ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 16Document updated
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