Answer
Caution is recommended because niraparib induces CYP1A2 in vitro, while clozapine has CYP1A2-dependent metabolism and a narrow therapeutic range; no clinical drug interaction studies have been performed with niraparib.
Sources for this answer
- Zejula 100mg TabletsGlaxoSmithKline UK · emc · SmPC §4.5 Interaction with other medicinal products · Version 8Document updated
Sources checked