Answer
Caution is needed when infusing esmolol hydrochloride 10 mg/ml in kidney impairment because renal excretion of its acid metabolite is significantly reduced, increasing the metabolite’s elimination half-life about tenfold and considerably elevating its plasma levels.
Sources for this answer
- Esmolol hydrochloride 10 mg/ml solution for injectionAOP Orphan Ltd · emc · SmPC §4.2 Posology and method of administration · Version 5Document updated
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