Answer
Caution is advised when prescribing oseltamivir with methotrexate because methotrexate is a co-excreted agent with a narrow therapeutic margin, although clinically important interactions involving competition for renal tubular secretion are unlikely.
Sources for this answer
- Tamiflu 30 mg, 45 mg and 75 mg Hard CapsulesRoche Products Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 36Document updated
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