Answer
APL commonly depends on an abnormal PML/RAR-alpha fusion protein. Arsenic trioxide promotes damage or degradation of this protein and helps abnormal promyelocytes mature or die.
Sources for this answer
- Trisenox (arsenic trioxide) 2mg/ml Concentrate for Solution for Infusion — Current selected SmPCemc · Summary of Product Characteristics
- PubMedPubMed · Reputable Web
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