Answer
Amsacrine is discouraged during pregnancy, especially the first trimester, because animal studies showed teratogenicity and other reproductive toxicity and its mechanism suggests possible fetal harm; human pregnancy data are insufficient, so treatment benefits must be weighed against fetal risks individually.
Sources for this answer
- Amsidine 75mg/1.5ml, concentrate and solvent for concentrate for solution for infusionEurocept International bv · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 1Document updated
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