Answer
In someone who still has a womb, systemic estradiol can thicken its lining. A progestogen usually protects against endometrial hyperplasia and cancer.
Sources for this answer
- NHSNHS · NHS medicine guidance
- Evorel Gel — Current selected SmPCemc · Summary of Product Characteristics
- Evorel 25 Patch, Evorel 50 Patch, Evorel 75 Patch and Evorel 100 Patch — Current selected SmPC