Answer
CYP2C19 affects how quickly mavacamten is cleared. Poor metabolisers may develop much higher concentrations and have a greater risk of reduced heart pumping function.
Sources for this answer
- Mavacamten BMS 2.5 mg, 5 mg, 10 mg, 15 mg hard capsulesemc · SmPC Current selected SmPC · Version 6
- NHSNHS · NHS medicine guidance