Answer
CYP2C19 affects how quickly mavacamten is cleared. Poor metabolisers may develop much higher concentrations and have a greater risk of reduced heart pumping function.
Sources for this answer
- Mavacamten BMS 2.5 mg, 5 mg, 10 mg, 15 mg hard capsules — Current selected SmPCemc · Summary of Product Characteristics
- NHSNHS · NHS medicine guidance
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.