ibuprofen + phenylephrine hydrochloride · Medicine question

Why does the phenylephrine in Nurofen Day & Night Cold & Flu tablets have reduced oral bioavailability?

Name: Why does the phenylephrine in Nurofen Day & Night Cold & Flu tablets have reduced oral bioavailability?
Published: 2026-11-08T14:21:06.642Z

iatroX medicinesPublished 8 November 2026

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The phenylephrine in Nurofen Day & Night Cold & Flu tablets has reduced oral bioavailability because of first-pass metabolism, although it is absorbed from the gastrointestinal tract.

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Nurofen Day & Night Cold & Flu 200mg/5mg TabletsReckitt Benckiser Healthcare (UK) Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 11Document updated 20 November 2024

Sources checked 8 November 2026

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