Answer
CellCept’s active metabolite MPA inhibits IMPDH and thus de novo guanosine nucleotide synthesis, on which T- and B-lymphocytes critically depend for proliferation, whereas other cells can use salvage pathways.
Sources for this answer
- Cellcept 500mg powder for concentrate for solution for infusionRoche Products Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 39Document updated
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