Answer
Most pemetrexed is removed unchanged by the kidneys. Reduced kidney function can increase exposure and toxicity, and pemetrexed itself can occasionally cause serious renal injury.
Sources for this answer
- Pemetrexed Sandoz 25 mg/ml Concentrate for solution for infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.