Answer
Pemetrexed is removed mainly unchanged through the kidneys. Reduced renal clearance can raise exposure and the risk of serious toxicity.
Sources for this answer
- Pemetrexed 25 mg/ml concentrate for solution for infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.