Answer
Ganciclovir is cleared mainly by the kidneys. Reduced kidney function increases exposure and toxicity risk, so treatment must be reviewed against current renal function.
Sources for this answer
- Valcyte 50 mg/ml powder for oral solutionemc · SmPC Current selected SmPC · Version 3
- Valcyte 450mg film-coated tabletsemc · SmPC Current selected SmPC · Version 3