Answer
Vigabatrin is mainly removed unchanged by the kidneys. Reduced kidney function can increase exposure and adverse effects such as sleepiness or confusion.
Sources for this answer
- Vigabatrin Zydus Pharmaceuticals UK 100 mg/ml Oral Solution — Current selected SmPCemc · Summary of Product Characteristics
- Sabril 500 mg film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
- Kigabeq (vigabatrin) 100mg — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.