Answer
Both components are cleared mainly through the kidneys. Reduced clearance can increase exposure and the risk of toxicity.
Sources for this answer
- Piperacillin/Tazobactam 4 g/0.5 g powder and solvent for solution for infusion — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.