Answer
The active circulating metabolite is substantially cleared through the kidneys, so impaired function increases exposure and toxicity risk. Severe renal impairment is a contraindication to the selected oral product.
Sources for this answer
- Fludara oral 10 mg film-coated tablet — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.