Answer
Digoxin is cleared mainly by the kidneys. Reduced kidney function can allow it to accumulate and increase toxicity risk.
Sources for this answer
- Digoxin 250 micrograms tablets — Current selected SmPCemc · Summary of Product Characteristics
- NHS Specialist Pharmacy ServiceNHS Specialist Pharmacy Service · NHS medicine guidance
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.