Answer
Certolizumab pegol (Cimzia) does not fix complement or cause antibody-dependent cell-mediated cytotoxicity in vitro because it lacks the fragment crystallisable (Fc) region normally present in a complete antibody.
Sources for this answer
- Cimzia 200 mg solution for injection in pre-filled syringeUCB Pharma Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 34Document updated
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