Answer
Impairment can reduce colchicine clearance and increase toxicity. Some interacting medicines are contraindicated when kidney or liver impairment is present.
Sources for this answer
- Colchicine 500 microgram Tablets — Current selected SmPCemc · Summary of Product Characteristics
- NHSNHS · NHS medicine guidance
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.