Answer
Canagliflozin has been associated with increased lower-limb amputation risk in some studies. New ulcers, infection, osteomyelitis or gangrene require prompt clinical review.
Sources for this answer
- Vokanamet 50 mg/1000 mg film coated tablets — Current selected SmPCemc · Summary of Product Characteristics
- UK GovernmentUK Government · Reputable Web