Answer
Ribociclib can increase blood creatinine by inhibiting the renal transporters OCT2 and MATE1, which actively secrete creatinine from the proximal tubules; any increase during treatment warrants further kidney function assessment to exclude renal impairment.
Sources for this answer
- Kisqali film coated tabletsNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 25Document updated
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