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Medicines LevothyroxineQuestion & answer

Levothyroxine · Medicine question

Why can proton pump inhibitors reduce levothyroxine absorption?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Proton pump inhibitors can reduce levothyroxine absorption because they increase intragastric pH, making the stomach less acidic.

Sources for this answer

Levothyroxine 25 micrograms TabletsWockhardt UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 11Document updated 11 July 2023

Sources checked 8 November 2026

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Levothyroxine

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