Answer
Cobicistat-containing products inhibit CYP3A, which is expected to increase systemic corticosteroid side effects with Gentisone HC Ear Drops; the combination should be avoided unless benefits outweigh the increased risk, with monitoring if used.
Sources for this answer
- Gentisone HC Ear Drops/ Gentamicin 0.3% w/v and Hydrocortisone acetate 1% w/v Ear DropsADVANZ Pharma · emc · SmPC §4.4 Special warnings and precautions for use · Version 10Document updated
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