ibuprofen + phenylephrine hydrochloride · Medicine question

Why are Nurofen Day & Night Cold & Flu tablets contraindicated with monoamine oxidase inhibitors (MAOIs)?

Name: Why are Nurofen Day & Night Cold & Flu tablets contraindicated with monoamine oxidase inhibitors (MAOIs)?
Published: 2026-11-08T01:53:44.048Z

iatroX medicinesPublished 8 November 2026

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Nurofen Day & Night Cold & Flu tablets are contraindicated with MAOIs because hypertensive interactions occur between MAOIs and phenylephrine hydrochloride, a sympathomimetic amine in the tablets.

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Nurofen Day & Night Cold & Flu 200mg/5mg TabletsReckitt Benckiser Healthcare (UK) Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 11Document updated 20 November 2024

Sources checked 8 November 2026

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