Answer
Kidney function affects dapagliflozin's glucose-lowering effect and metformin clearance. Reduced clearance can increase metformin accumulation and lactic-acidosis risk.
Sources for this answer
- Dapagliflozin/ Metformin hydrochloride — Current selected SmPCemc · Summary of Product Characteristics
- Xigduo 5 mg/1,000 mg film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
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