Which urea cycle enzyme deficiencies is Ammonaps (sodium phenylbutyrate) indicated to help manage?

Ammonaps (sodium phenylbutyrate) is adjunctive therapy for chronic management of carbamylphosphate synthetase, ornithine transcarbamylase or argininosuccinate synthetase deficiencies in all neonatal-onset cases (complete deficiencies; first 28 days) and late-onset cases (partial deficiencies; after the first month) with prior hyperammonaemic encephalopathy.