fosaprepitant dimeglumine · Medicine question

Which receptors does fosaprepitant's active metabolite aprepitant block to produce its antiemetic effect?

Name: Which receptors does fosaprepitant's active metabolite aprepitant block to produce its antiemetic effect?
Published: 2026-11-08T14:21:19.344Z

iatroX medicinesPublished 8 November 2026

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Aprepitant, fosaprepitant’s active metabolite, selectively blocks human substance P neurokinin 1 (NK₁) receptors with high affinity.

Sources for this answer

IVEMEND 150 mg powder for solution for infusionMerck Sharp & Dohme (UK) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 16Document updated 24 February 2022

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