Answer
Difelikefalin acetate activates kappa opioid receptors on peripheral sensory neurons and immune cells, which is considered responsible for its itch-reducing effects.
Sources for this answer
- Kapruvia (Difelikalin)Vifor Fresenius Medical Care Renal Pharma UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated
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