crizotinib · Medicine question

Which receptor tyrosine kinases does crizotinib inhibit?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Crizotinib inhibits ALK and its oncogenic variants (ALK fusion events and selected ALK mutations), hepatocyte growth factor receptor (HGFR, c-Met), ROS1 (c-ros), and Recepteur d'Origine Nantais (RON) receptor tyrosine kinases.

Sources for this answer

Xalkori 200mg hard capsulePfizer Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 37Document updated 25 February 2025

Sources checked 8 November 2026

Explore this learning need in CPDTake this topic to CPD, then choose your learning context and available question library.

Can crizotinib affect fertility in men and women?Do Xalkori 200 mg crizotinib hard capsules require special storage conditions?Does the shell of Xalkori 200 mg crizotinib hard capsules contain gelatin?How are Xalkori crizotinib granules administered after opening the capsule?How should unused Xalkori 200 mg crizotinib hard capsules or waste material be disposed of?What allergy-related contraindication applies to Xalkori crizotinib capsules?

loading page…

Answer

Sources for this answer

More questions about crizotinib

Answer

Sources for this answer

More questions about crizotinib

crizotinib

More clinical questions?