plerixafor · Medicine question

Which receptor does plerixafor block, and which ligand does it prevent from binding?

Name: Which receptor does plerixafor block, and which ligand does it prevent from binding?
Published: 2026-11-08T14:28:00.261Z

iatroX medicinesPublished 8 November 2026

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Answer

Plerixafor selectively and reversibly antagonises the CXCR4 chemokine receptor, preventing binding of stromal cell-derived factor-1α (SDF-1α), also known as CXCL12.

Sources for this answer

Plerixafor Seacross 20 mgml solution for injectionSeacross Pharmaceuticals Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 2Document updated 13 December 2024

Sources checked 8 November 2026

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