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Medicines isatuximabQuestion & answer

isatuximab · Medicine question

Which receptor does isatuximab target on multiple myeloma cells?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Isatuximab targets a specific extracellular epitope of the CD38 receptor, a transmembrane glycoprotein highly expressed on multiple myeloma cells.

Sources for this answer

SARCLISA 20mg/mL concentrate for solution for infusionSANOFI · emc · SmPC §5.1 Pharmacodynamic properties · Version 10Document updated 17 June 2026

Sources checked 8 November 2026

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Is intravenous Sarclisa (isatuximab) indicated for induction treatment in adults with newly diagnosed multiple myeloma who are eligible for autologous stem cell transplant?Can isatuximab cause neutropenia?Can Sarclisa (isatuximab) 20 mg/mL concentrate for solution for infusion be mixed with other medicinal products?Does isatuximab affect the pharmacokinetics of pomalidomide or vice versa?For how long after stopping isatuximab should women of childbearing potential continue using effective contraception?Has heart failure been reported in patients receiving isatuximab with carfilzomib and dexamethasone?

isatuximab

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