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Medicines evinacumabQuestion & answer

evinacumab · Medicine question

Which protein does evinacumab bind to and inhibit?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Evinacumab specifically binds to and inhibits ANGPTL3, a member of the angiopoietin-like protein family.

Sources for this answer

Evkeeza 150 mg/ml concentrate for solution for infusionUltragenyx UK · emc · SmPC §5.1 Pharmacodynamic properties · Version 4Document updated 9 January 2026

Sources checked 8 November 2026

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evinacumab

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By what route is Evkeeza (evinacumab) administered?Can Evkeeza (evinacumab) affect the ability to drive or use machines?How long is effective contraception recommended during and after treatment with evinacumab?How much proline does Evkeeza (evinacumab) concentrate contain per ml, and why is this relevant to patients with hyperprolinaemia?What are the most frequently reported adverse reactions to evinacumab?What is Evkeeza (evinacumab) used to treat, and from what age is it indicated?

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