Which potentially life-threatening skin reactions have been reported with the bumetanide component of amiloride hydrochloride + bumetanide?

Toxic epidermal necrolysis (TEN) and Stevens–Johnson syndrome (SJS), which can be life-threatening or fatal, have been reported with non-antibiotic sulphonamide-containing products, including the bumetanide component of amiloride hydrochloride + bumetanide.