Answer
Tolcapone (Tasmar) is indicated with levodopa/benserazide or levodopa/carbidopa for levodopa-responsive idiopathic Parkinson's disease with motor fluctuations when other COMT inhibitors have failed or are not tolerated; it is not a first-line adjunct because of potentially fatal acute liver injury.
Sources for this answer
- Tasmar 100 mg film-coated tabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §4.1 Therapeutic Indications · Version 4Document updated
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