Answer
In atorvastatin + ezetimibe, atorvastatin selectively and competitively inhibits HMG-CoA reductase, while ezetimibe targets the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1), inhibiting intestinal uptake of cholesterol and phytosterols.
Sources for this answer
- Ezetimibe/Atorvastatin 10 mg/10 mg Film-coated TabletRoma Pharmaceuticals Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated
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