Aprocitentan · Medicine question

Which medicines should be checked before starting?

iatroX medicinesPublished 14 August 2026Reviewed 14 August 2026

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All medicines should be reviewed. Methotrexate, tizanidine and similar narrow-therapeutic-index medicines are particularly important because aprocitentan may alter their exposure.

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JERAYGO 12.5 mg film-coated tabletsemc · SmPC Current selected SmPC · Version 1

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Why is aprocitentan added to other blood-pressure medicines?Does it replace my existing blood-pressure medicines?Can JERAYGO be taken with food?Can the tablet be split or crushed?Why can aprocitentan cause swollen ankles?What blood tests may be needed?

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