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Medicines fentanylQuestion & answer

fentanyl · Medicine question

Which liver enzyme primarily metabolises fentanyl?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Fentanyl is primarily metabolised by CYP3A4 in the liver.

Sources for this answer

Durogesic DTrans 12 mcg/hr Transdermal PatchJanssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §5.2 Pharmacokinetic properties · Version 50Document updated 18 September 2025

Sources checked 8 November 2026

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fentanyl

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