Answer
In human cells, tofacitinib citrate preferentially inhibits signalling by heterodimeric cytokine receptors associated with JAK3 and/or JAK1, with functional selectivity over cytokine receptors signalling via pairs of JAK2.
Sources for this answer
- XELJANZ 5mg film-coated tabletsPfizer Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 33Document updated
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