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Medicines leflunomideQuestion & answer

leflunomide · Medicine question

Which enzyme does the active metabolite of leflunomide inhibit?

iatroX medicinesPublished 8 November 2026

The answer

Answer

A771726, the active metabolite of leflunomide, inhibits the human enzyme dihydroorotate dehydrogenase (DHODH).

Sources for this answer

Leflunomide 20 mg Film-coated TabletsSandoz Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 15Document updated 22 July 2025

Sources checked 8 November 2026

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leflunomide

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