entacapone · Medicine question

Which enzyme does entacapone inhibit, and does this inhibition occur mainly centrally or peripherally?

Name: Which enzyme does entacapone inhibit, and does this inhibition occur mainly centrally or peripherally?
Published: 2026-11-08T13:46:18.767Z

iatroX medicinesPublished 8 November 2026

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Entacapone reversibly and specifically inhibits catechol-O-methyl transferase (COMT), acting mainly in peripheral tissues rather than centrally.

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Entacapone Mylan 200 mg film-coated tabletsViatris (formerly Mylan or Upjohn) · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated 14 December 2017

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