Answer
In VIMOVO, 30% of naproxen is metabolised by CYP enzymes, primarily CYP2C9, while esomeprazole is metabolised mainly by CYP2C19 and otherwise by CYP3A4; in poor CYP2C19 metabolisers, esomeprazole metabolism is probably mainly catalysed by CYP3A4.
Sources for this answer
- VIMOVO 500 mg/20 mg modified-release tabletsGrunenthal Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 21Document updated
Sources checked