Answer
Thrombocytopenia and agranulocytosis have been reported with caffeine + paracetamol under post-marketing data for paracetamol; their frequency is unknown but likely very rare (less than 1 in 10,000).
Sources for this answer
- Paracetamol and Caffeine 500mg / 65mg TabletsFlamingo Pharma (UK) Ltd · emc · SmPC §4.8 Undesirable effects · Version 1Document updated
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