Answer
The trimethoprim component of sulfamethoxazole + trimethoprim reversibly inhibits bacterial dihydrofolate reductase (DHFR), which converts dihydrofolate to tetrahydrofolate in the folate metabolic pathway.
Sources for this answer
- Co-Trimoxazole 16 mg/ 80 mg per ml for Infusion.Aspen · emc · SmPC §5.1 Pharmacodynamic properties · Version 17Document updated
Sources checked