What symptoms can indicate differentiation syndrome during ivosidenib treatment for acute myeloid leukaemia?

During ivosidenib treatment for acute myeloid leukaemia, differentiation syndrome symptoms include non-infectious leukocytosis, peripheral oedema, fever, dyspnoea, pleural or pericardial effusion, hypotension, hypoxia, pulmonary oedema, pneumonitis, rash, fluid overload, tumour lysis syndrome and increased creatinine; contact your physician immediately if these occur.