What serious eye complications can occur with long-term or excessively frequent use of Minims Oxybuprocaine Hydrochloride eye drops?

Long-term and/or excessively frequent use of Minims Oxybuprocaine Hydrochloride eye drops may, in very rare cases, cause keratopathy, hypopyon or central corneal erosion including central scarring; corneal perforation may also be possible.