Answer
Taking tramadol with gabapentin or pregabalin may cause respiratory depression, low blood pressure, profound sedation, coma or death through additive central nervous system depression, so the dose and duration of combined use should be limited.
Sources for this answer
- Zamadol Capsules 50 mgViatris (formerly Mylan or Upjohn) · emc · SmPC §4.5 Interaction with other medicinal products · Version 21Document updated
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